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The concomitant utilization of ROXICODONE and CYP3A4 inhibitors can raise the plasma focus of oxycodone, leading to elevated or extended opioid results. These effects can be far more pronounced with concomitant use of ROXICODONE and CYP2D6 and CYP3A4 inhibitors, particularly when an inhibitor is added after a stable dose of ROXICODONE is obtained [